Location
Hammersmith, London

Hours
Full-time

Salary
£42,694 per annum plus London allowance of £5,560 per annum. Additional allowances include a £1,000 lump sum settlement allowance plus a yearly Training Allowance of £850 in the first year (paid monthly), increasing to £1,300 in year two and £1,800 in year three.

About the Role
The Genomic Variation and Disease Group at UKRI works at the intersection of medical genetics, bioinformatics, and molecular biology to explore mechanisms underlying human diseases. Using CRISPR/Cas9 genome editing and synthetic genomics, the group models disease-causing chromosomal structural variants (SVs) in mouse or human genomes to study their functional consequences. The challenge is to understand how genomic variation affects molecular and cellular processes to influence organismal phenotypes.

We are seeking a talented postdoctoral scientist with a background in molecular biology to join our collaborative team. You will contribute to studying molecular mechanisms of gene regulation and develop scalable platforms for engineering patient-specific structural variants. Your work will involve in vitro cellular differentiation and/or in vivo mouse models, CRISPR/Cas9 genome editing, high-throughput CRISPR screens, and single-cell technologies to investigate molecular consequences of SVs impacting the noncoding genome.

Our newly established lab is committed to fostering a welcoming and supportive environment where diversity and collaboration thrive. We focus on cutting-edge basic and translational science and provide extensive on-the-job training. At LMS, excellent mentoring and support are available to help you achieve your career goals. You will have opportunities to work with a broad network of collaborators, attend scientific conferences, and publish your research in leading journals.

Experience
- Background in gene regulation and/or developmental genetics
- Experience in mouse ES cell culture and common molecular biology techniques
- Experience in CRISPR/Cas9 genome editing and high-throughput CRISPR screens
- Experience in preparation of targeted NGS libraries (advantageous)
- Experience in in vitro neuronal differentiation (advantageous)
- Experience in immunofluorescence and microscopy imaging (advantageous)
- Experience in single-cell technologies (advantageous)
- Experience in high-throughput chromosome conformation capture (cHi-C) (advantageous)
- Experience in ATAC-seq and Cut&Tag/ChIP-seq (advantageous)

About you
- Ability to conduct reproducible research
- Ability to review recent literature in detail
- Creative problem-solving skills
- Keen interest in learning new skills
- Excellent verbal and written communication skills in English
- Ability to motivate others and work cooperatively in a team
- Strong organisational skills with ability to prioritise and work independently
- Advanced computer skills including word processing, spreadsheets, and internet use
- Flexible and open-minded attitude
- Discipline and regard for confidentiality and security
- Willingness to undertake necessary training

Qualifications
- Essential: PhD (or equivalent) in Molecular Genetics or a closely related discipline
- Excellent written communication skills in English with ability to write clearly for publication