Location
Hammersmith, London

Hours
Full-time

Salary
£42,694 plus London allowances of £5,560 per annum* Additional allowances include a £1,000 lump sum settlement allowance plus a yearly Training Allowance of £850 in the first year, increasing to £1,300 in year two and £1,800 in year three, paid in monthly instalments.

About the Role
Understanding how chemicals in our environment cause disease has been constrained by a fundamental lack of tools. The Tissue Biology Group is building spatial single-cell genomics technologies and high-throughput screening platforms to reveal, cell by cell, how exposures remodel tissues and drive disease. The group develops new methods for single-cell spatial multiomics, in vitro and in vivo screening, and computational analysis of these data. This postdoctoral position offers the opportunity to establish the group's exposure screening capability by building screening platforms that enable parallel assays of many exposures and developing molecular and phenotypic readouts to make those screens informative.

The role follows one of two strands shaped by the candidate's background and interests:
- The in vitro strand: establishing novel screening platforms using organoid, primary cell, or comparable human-relevant culture systems with multiplexed, sequencing-based readouts for testing multiple compounds and doses in parallel.
- The in vivo strand: establishing novel screening approaches to assay exposures in tissue at a scale beyond conventional study designs. This requires hands-on in vivo experience and a UK Home Office personal licence or readiness to obtain one.

This is a method-development post with broad reach, with potential for collaboration and commercialisation. The successful candidate will generate their own data at the bench and take primary responsibility for data analysis, supported by the group and LMS core facilities in genomics, flow cytometry, microscopy, metabolomics, physiology, imaging, and scientific computing. The group values curiosity, creativity, collaboration, and mentorship, offering scope to shape the project direction and grow as a scientist.

Members are encouraged to present at international meetings and publish work with documented and shared methods.

Experience
- Molecular and cell biology expertise.
- Experience in experimental screening and/or computational analysis of high-dimensional biological data, with aptitude for both.
- Programming skills in R and/or Python for sequencing and screening data analysis.
- Experience in screen design, execution, and analysis is advantageous.
- Established hands-on in vivo experience and a UK Home Office personal licence required for the in vivo strand; otherwise advantageous.
- Experience with organoid or advanced in vitro culture systems and new approach methodologies (NAMs) is advantageous.
- Background in toxicology, exposomics, mutagenesis, or environmental health is advantageous.
- Experience in laboratory automation, liquid handling, or assay miniaturisation is advantageous.
- Knowledge of HPC environments is advantageous.
- Proven ability to develop new methods and analyse, visualise, and disseminate high-dimensional data.

About you
- Ability to conduct reproducible research and detailed literature reviews.
- Creative problem-solving skills and persistence.
- Keen interest in learning new wet and dry lab skills.
- Excellent verbal and written communication skills in English.
- Ability to motivate others and work collaboratively.
- Strong organisational skills with minimal supervision.
- Flexible attitude and willingness to undertake necessary training.
- Discipline and regard for confidentiality and security.

Qualifications
- Essential: PhD (or equivalent experience) in molecular or cell biology, genomics, toxicology, computational biology, or a closely related discipline.
- Desirable: First-author publication, preprint, or manuscript in preparation.
- UK Home Office personal licence is desirable.